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We are seeking a creative, self-motivated, collaborative Contractor/Scientist-II to join the Nucleic Acid Design and Discovery (NADD) team within the ProteinSciences (PS) department at our organization. The role requires experience in oligonucleotide discovery and synthesis to support our new oligonucleotide therapeutics discovery group. Experience in the delivery of oligonucleotide therapeutics and large molecule drug discovery would be preferred. The successful candidate will join an interdisciplinary chemistry team working in RNAi biology research and will contribute positively to its developing culture.

Key Responsibilities

Work in an oligonucleotide therapeutic drug discovery research lab and interface across different therapeutic areas, including neuroscience, immunology, and oncology, to help build a comprehensive therapeutic discovery strategy.
Troubleshoot oligonucleotide synthesis and impurity profiling.
Collaborate with other scientists to maintain common lab equipment such as oligo synthesizers, HPLC, and desalting units.
Perform literature reviews, propose, and execute nucleic acid chemistry plans, and coordinate chemistry and biology data to support oligonucleotide compound progression.
Establish methods for scaled-up synthesis of lead molecules and coordinate material delivery for preclinical studies.
Maintain a high level of productivity in the laboratory setting to meet the timelines for in vitro and in vivo studies.

Requirements

Required

Hands-on experience in oligonucleotide synthesis using automated oligo synthesizers.
Proficiency in nucleic acid chemistry.

Preferred

Experience in oligonucleotide purification and characterization using HPLC and mass spectrometry.
Understanding of nucleic acid therapeutic modalities, modification chemistries, sequence selection, and mechanism of action.
Experience in oligonucleotide therapeutics, large molecule drug discovery, oligonucleotide delivery, or bio-conjugation.
Strong problem-solving, analytical, communication, and organizational skills.
Good communication and interpersonal skills.
Pharmaceutical or biotechnology industry experience in research and development of RNAi therapeutics.

Additional Details

Assignment Duration: 12 Months
Work Schedule: Monday to Friday, Standard 8-hour shift

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